Antimetastatic potential of anthocyanins from Cordyline australis (G. Forst.) Endl. Red star variety on MCF onco cell lines

Breast cancer is the second most deadly diagnosed lifestyle disease among women. Surgery and chemotherapy are current treatments of choice; nevertheless, toxicity connected with this underscores urgency demand for human-friendly drug. 50% synthetic drugs available commercially today either direct or indirect descendants extracted from herbs. Anthocyanins possess many pharmacological activities, including anticancer potential. However, no study on activity anthocyanins Cordyline australis has been reported. were fresh leaves using ethanol as solvent. The total anthocyanin was quantified fractionated by Ultra Performance Liquid Chromatography. Cytotoxicitic effect carried diverse cell lines like MCF 7, HCT-116, Caco-2 SW480 MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. Based data, 7 cells further analyzed LDH assay, Glutathione-S- transferase (GST), Quercetin reductase, Cytochrome P450 Caspase 3, 8 9 activities. obtained results ANOVA a level significance. Results assay revealed that extract significant toxic (p < 0.05) specificity against (65 ± 2.1 at 50 µg/ml) when compared to other onco cells. Remarkable leakage (50.2% vs µg/ml), GST (3.0±0.002 U/mg protein), QR (4.4±0.054 Cyt activities (0.291±0.01 protein) noticed. 3 (157%), (142%) (147%) displayed profound These in vitro findings specific effects noticed C. require evaluation animal models. Finally, open up possibility developing lead antimetastatic candidate breast cancer.